2024
Weingarten, P.; Adams, F.; Silver-Mediated ARGET-ATRP of Reactive Acrylates Using TPMANMe2 Ligand: A Universal Strategy for Controlled Copolymerization, ACS Macro Lett. 2024, 13 (10), 1318-1324. https://doi.org/10.1021/acsmacrolett.4c00621
Hurst, J.; Adams, F.; Schnichels, S., The Future of Nanomaterials Tackling the Challenge of Delivering Nucleic Acids to the Retina. Adv. Funct. Mat. accepted. https://doi.org/10.1002/adfm.202407173
Adams, F., Merging σ-Bond Metathesis with Polymerization Catalysis: Insights into Rare-Earth Metal Complexes, End-Group Functionalization and Application Prospects, Macromol. Rapid Commun. 2024, 45, 2400122. https://doi.org/10.1002/marc.202400122
Adams, F.; Zimmermann, C. M.; Baldassi, D.; Pehl, T. M.; Weingarten, P.; Kachel, I.; Kranzlein, M.; Jurgens, D. C.; Braubach, P.; Alexopoulos, I.; Wygrecka, M.; Merkel, O. M.*, Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis. Small 2024, 20 (22), 2308775. https://doi.org/10.1002/smll.202308775
Brendel, J. C.; Adams, F., Supramolekulare Polymere. In Lechner, Gehrke, Nordmeier - Makromolekulare Chemie: Ein Lehrbuch für Chemiker, Physiker, Materialwissenschaftler und Verfahrenstechniker, Seiffert, S.; Susoff, M.; Kummerlöwe, C., Eds. Springer Berlin Heidelberg: Berlin, Heidelberg, 2024; pp 885-944. https://doi.org/10.1007/978-3-662-69248-6_7
Jin, Y.; Wang, X.; Kromer, A. P. E.; Müller, J. T.; Zimmermann, C.; Xu, Z.; Hartschuh, A.; Adams, F.; Merkel, O. M. Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage. Biomacromolecules 2024, 25, 7, 4177–4191. https://doi.org/10.1021/acs.biomac.4c00283
Al-Shok, L.; Haddleton, D. M.; Adams, F., Progress in Catalytic Ring-Opening Polymerization of Biobased Lactones. In Synthetic Biodegradable and Biobased Polymers: Industrial Aspects and Technical Products; Künkel, A., Battagliarin, G., Winnacker, M., Rieger, B., Coates, G., Eds.; Springer International Publishing: Cham, 2024; pp 197-267. https://doi.org/10.1007/12_2021_111
Halama, K.; Lin, M. T.-Y.; Schaffer, A.; Foith, M.; Adams, F.; Rieger, B., Cytocompatible Triblock Copolymers with Controlled Microstructure Enabling Orthogonally Functionalized Bio-polymer Conjugates. Macromolecules 2024, 57 (4), 1438−1447. https://pubs.acs.org/doi/10.1021/acs.macromol.4c00692
2023 - 2020
Hornberger, L.-S.; Weingarten, P.; Lange, P. L.; Schleid, T.; Adams, F.*, Connecting 16- with 4-Membered Rings: Ring-Opening Polymerization of Bio-Based ω-Pentadecalactone with Amino-Alkoxy-Bis(phenolate) Yttrium Initiators and Copolymerization with β-Butyrolactone. Eur. Polym. J. 2023, 199, 112449. https://doi.org/10.1016/j.eurpolymj.2023.112449
Hamedani, Y. P.; Çakırefe, S.; Fietz, A.; Hurst, J.; Schnichels, S.; Adams, F.*, The Effect of MPEGA/EHA Ratio and Copolymer Composition on the Solution Behaviour of Amphiphilic, Comb-Shape Copolymers Synthesized via Cu(0)-mediated SET-LRP for Potential Drug Delivery Applications. Macromol. Chem. Phys. 2023, 224, 2300226.https://doi.org/10.1002/macp.202300226 (Special Issue: 80 Years of MCP: The Next Generation of Polymer Researchers)
Adams, F.; Zimmermann, C. M.; Luciani, P.; Merkel, O. M.*, Chapter 9 - Microfluidics for nanopharmaceutical and medical applications. In Microfluidics for Cellular Applications, Perozziello, G.; Krühne, U.; Luciani, P., Eds. Elsevier: 2023; pp 343-408. https://doi.org/10.1016/B978-0-12-822482-3.00010-5
Jin, Y.; Adams, F.; Möller, J.; Isert, L.; Zimmermann, C. M.; Keul, D.; Merkel, O. M.*, Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends. Macromol. Biosci. 2023, 23 (2), e2200409. https://doi.org/10.1002/mabi.202200409
Jin, Y.; Adams, F.; Nguyen, A.; Sturm, S.; Carneiro, S. P.; Müller-Caspary, K.; Merkel, O.M.*, Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery. Nanoscale Adv. 2023. https://doi.org/10.1039/D3NA00272A
Jin, Y.; Adams, F.; Isert, L.; Baldassi, D.; Merkel, O. M.*, Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer. Mol. Pharm. 2023. https://doi.org/10.1021/acs.molpharmaceut.3c00206
Gabold, B.; Adams, F.; Brameyer, S.; Jung, K.; Ried, C. L.; Merdan, T.; Merkel, O. M.*, Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. Drug Deliv. Transl. Res. 2023, 13 (3), 822-838. https://doi.org/10.1007/s13346-022-01245-z
Moinet, E. C.; Tardif, O.; Hornberger, L.-S.; Adams, F.; Maichle-Mössmer, C.; Anwander, R.*, Discrete Trivalent Lanthanide Isobutylaluminates in Isoprene Polymerization: Elucidation of Cationized Active Species. ACS Catal. 2023, 12826-12834. https://doi.org/10.1021/acscatal.3c02247
Hartl, N.; Gabold, B.; Adams, F.; Uhl, P.; Oerter, S.; Gatzner, S.; Metzger, M.; Konig, A. C.; Hauck, S. M.; Appelt-Menzel, A.; Mier, W.; Fricker, G.; Merkel, O. M.*, Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models. J. Control. Release 2023. https://doi.org/10.1016/j.jconrel.2023.07.019
Adams, F.*; Merkel, O. M.,Microfluidics for Nanoencapsulation of Nucleic Acids Using Polymeric Carriers, Material Matters, 2022, 17.2. https://www.sigmaaldrich.com/DE/de/technical-documents/technical-article/materials-science-and-engineering/drug-delivery/microfluidics-nanoencapsulation-nucleic-acids-polymeric-carriers
Merkel, O. M.; Adams, F.; Zimmermann, C. M.; Baldassi, D, Process for synthesizing poly(spermine acrylamide) and/or poly(spermine acrylamide-co-N-alkylacrylamide) and their application. European Patent Application No. EP 22 162 499.2. Application Date: March 16th, 2022.
Adams, F.; Rieger, B., Process for polymerizing beta-butyrolactone, U.S. Patent 11 459 423, Oct. 04, 2022.
Hornberger, L.-S.; Adams, F.*, Photocatalytic CO2 Conversion Using Metal-Containing Coordination Polymers and Networks: Recent Developments in Material Design and Mechanistic Details. Polymers, 2022,14 (14), 2778. https://doi.org/10.3390/polym14142778
Oliveira-Filho, E. R.; de Macedo, M. A.; Lemos, A. C. C.; Adams, F.; Merkel, O. M.; Taciro, M. K.; Gomez, J. G. C.; Silva, L. F.*, Engineering Burkholderia sacchari to enhance poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] production from xylose and hexanoate. Int. J. Biol. Macromol., 2022, 213, 902-914. https://doi.org/10.1016/j.ijbiomac.2022.06.024.
Kränzlein, M.; Pehl, T. M.; Adams, F.*; Rieger, B.*, Uniting Group-Transfer and Ring-Opening Polymerization─Block Copolymers from Functional Michael-Type Monomers and Lactones. Macromolecules 2021, 54 (23), 10860-10869. 10.1021/acs.macromol.1c01692.
Pehl, T. M.; Adams, F.; Kränzlein, M.; Rieger, B.*, Expanding the Scope of Organic Radical Polymers to Polyvinylphosphonates Synthesized via Rare-Earth Metal-Mediated Group-Transfer Polymerization. Macromolecules 2021, 54 (9), 4089-4100.10.1021/acs.macromol.1c00217.
Keil, T. W.; Zimmermann, C.; Baldassi, D.; Adams, F.; Friess, W.; Mehta, A.; Merkel, O. M.*, Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles. Adv. Ther. 2021, 4 (6). 10.1002/adtp.202100073.
Isert, L.; Mehta, A.; Adams, F.; Merkel, O. M.*, Tracking siRNA–Nanocarrier Assembly and Disassembly Using FRET. In: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery. Springer US: New York, NY, 2021; pp 383-396.
Hartl, N.; Adams, F.; Merkel, O. M.*, From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood-brain barrier. Adv. Ther. 2021, 4 (1), 2000092. 10.1002/adtp.202000092.
Pehl, T. M.; Kränzlein, M.; Adams, F.; Schaffer, A.; Rieger, B.*, C–H Bond Activation of Silyl-Substituted Pyridines with Bis (Phenolate) Yttrium Catalysts as a Facile Tool towards Hydroxyl-Terminated Michael-Type Polymers. Catalysts 2020, 10 (4), 448. 10.3390/catal10040448.
Adams, F.; Pehl, T. M.; Kränzlein, M.; Kernbichl, S. A.; Kang, J.-J.; Papadakis, C. M.; Rieger, B.*, (Co)polymerization of (−)-menthide and β-butyrolactone with yttrium-bis(phenolates): tuning material properties of sustainable polyesters. Polym. Chem. 2020, 11 (27), 4426-4437. 10.1039/D0PY00379D.
2019 - 2015
Hartl, N.; Adams, F.; Costabile, G.; Isert, L.; Döblinger, M.; Xiao, X.; Liu, R.; Merkel, M. O.*, The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells. Nanomaterials 2019, 9 (7). 910.3390/nano9070986.
Adams, F.; Pahl, P.; Rieger, B.*, Metal‐catalyzed group‐transfer polymerization: a versatile tool for tailor‐made functional (Co) polymers. Chem. Eur. J. 2018, 24 (3), 509-518. 10.1002/chem.201703965.
Adams, F.; Pschenitza, M.; Rieger, B.*, Yttrium‐Catalyzed Synthesis of Bipyridine‐Functionalized AB‐Block Copolymers: Micellar Support for Photocatalytic Active Rhenium‐Complexes. ChemCatChem 2018, 10 (19), 4309-4316. 10.1002/cctc.201801009.
Adams, F.; Machat, M. R.; Altenbuchner, P. T.; Ehrmaier, J.; Pöthig, A.; Karsili, T. N.; Rieger, B.*, Toolbox of nonmetallocene lanthanides: multifunctional catalysts in group-transfer polymerization. Inorg. Chem. 2017, 56 (16), 9754-9764. 10.1021/acs.inorgchem.7b01261.
Kernbichl, S.; Reiter, M.; Adams, F.; Vagin, S.; Rieger, B.*, CO2-controlled one-pot synthesis of AB, ABA block, and statistical terpolymers from β-butyrolactone, epoxides, and CO2. J. Am. Chem. Soc. 2017, 139 (20), 6787-6790. 10.1021/jacs.7b01295.
Vagin, S. I.; Kronast, A.; Altenbuchner, P. T.; Adams, F.; Sinkel, C.; Deglmann, P.; Loos, R.; Schuffenhauer, T.; Sommer, B.; Bruck, T.; Rieger, B.*, Enzymatic degradation of synthetic poly(3-hydroxybutyrates) as a tool for combinatorial microstructure determination. Polym. Degrad. Stab. 2017, 143, 176-185. 10.1016/j.polymdegradstab.2017.07.007.
Adams, F.; Altenbuchner, P.; Werz, P.; Rieger, B.*, Multiresponsive micellar block copolymers from 2-vinylpyridine and dialkylvinylphosphonates with a tunable lower critical solution temperature. RSC Adv. 2016, 6 (82), 78750-78754. 10.1039/c6ra17160e.
Altenbuchner, P. T.; Werz, P. D.; Schöppner, P.; Adams, F.; Kronast, A.; Schwarzenböck, C.; Pöthig, A.; Jandl, C.; Haslbeck, M.; Rieger, B.*, Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells. Chem. Eur. J. 2016, 22 (41), 14576-14584. 10.1002/chem.201601822.
Adams, F., Gruppentransferpolymerisation von Michael-Monomeren: Untersuchung von C1-symmetrischen Komplexen. Springer Best Masters, Springer-Verlag, 2016. ISBN: 3658135743.
Altenbuchner, P.; Adams, F.; Kronast, A.; Herdtweck, E.; Pöthig, A.; Rieger, B.*, Stereospecific catalytic precision polymerization of 2-vinylpyridine via rare earth metal-mediated group transfer polymerization with 2-methoxyethylamino-bis (phenolate)-yttrium complexes. Polym. Chem. 2015, 6 (38), 6796-6801. 10.1039/c5py01146a.
Selected Publications
Polyvinylphosphonates as Organic Radical Polymers
The synthesis of organic radical polymers (ORPs) is expanded to the field of rare-earth metal-mediated group-transfer polymerization (REM-GTP).
Photo: (c) American Chemical Society, Dr. Johannes Richers
Metal-Catalyzed Group-Transfer Polymerization
The symbiosis of group-transfer polymerization and functional materials: Metal-catalyzed group-transfer polymerization has made major contributions to the precise synthesis of macromolecules to give access to a plethora of homo- and copolymers based on polar vinyl monomers. Thereby, GTP has established its potential to design functional and smart polymers. This concept article illustrates the significant progress in metal-catalyzed GTP focusing on functional (co)polymers including various polymeric architectures.
(Co)polymerization of (−)-menthide and β-butyrolactone with yttrium-bis(phenolates)
Yttrium-bis(phenolate) complexes were investigated in ring-opening polymerization of racemic β-butyrolactone (rac-BBL) and (−)-menthide. In addition, AB and BAB copolymers from poly((−)-menthide) (PM, block A) and poly(3-hydroxybutyrate) (PHB, block B) were synthesized via sequential addition.